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Evidence is increasing that every addiction without exception is related to issues with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both whenever they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the those who go through it one should err assisting caution and allow FDA do its job and demand some investigation be done so the public is aware of the side effects and risks of the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say anything to keep people on his or her medications.

Researchers found out that participants taking this drug for any year, lost excess weight within one month and have kept the load off throughout the 56 weeks with the study. Contrave is often a combination from the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which might be made up of more than one active ingredient, which might make them more potent and safer.

Combo-pilling will be the newest fad or in addition to this the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that at the time of right now there are no long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be authorized by the FDA.

Seizures are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug can also raise blood pressure and heart rate, and shouldn't be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise hypertension and heart rate and must stop used in patients with uncontrolled high blood pressure levels, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients on the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.

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